Spatial Organization of LCK as a Regulatory Mechanism of TCR Signalling

Abstract

To function in an immune response, T cell become activated when the interactions between the T cell receptor and the kinase Lck on the cell surface results in intracellular signals. Here, we will investigate how the kinase is organized on the cell surface during receptor activation and what intrinsic and extrinsic parameters regulate its organization. The research is based on novel single molecule imaging tools and will provide new insights into the regulation of T cell activation.

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Distinct mechanisms regulate Lck spatial organization in activated T cells

N Kapoor-Kaushik, E Hinde, EB Compeer, Y Yamamoto, F Kraus, Z Yang, J Lou, SV Pageon, T Tabarin, K Gaus, J Rossy

2016-03-08

Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. Th..